AMD Instinct MI350X vs NVIDIA B300 — GPU Comparison (Jul 2026)
AMD Instinct MI350X (288GB HBM3e, 1,800 TFLOPS FP16, CDNA 4) vs NVIDIA B300 (288GB HBM3e, 2,250 TFLOPS FP16, Blackwell Ultra)
Bottom Line: AMD Instinct MI350X vs NVIDIA B300
NVIDIA B300 comes out ahead overall, leading in 2 of 3 compared categories.
Where AMD Instinct MI350X leads
- TDP (1000W vs 1400W)
Where NVIDIA B300 leads
- FP16 (2,250 TFLOPS vs 1,800 TFLOPS)
- FP32 (75 TFLOPS vs 72 TFLOPS)
Choose AMD Instinct MI350X for Next-gen AI training, inference at scale. Choose NVIDIA B300 for Frontier AI training, largest model workloads.
Frequently Asked Questions
Is AMD Instinct MI350X or NVIDIA B300 better?
NVIDIA B300 leads in 2 of 3 compared categories. The right choice still depends on the factors that matter most to you.
Which has a better FP16, AMD Instinct MI350X or NVIDIA B300?
NVIDIA B300 (2,250 TFLOPS vs 1,800 TFLOPS).
Which has a better FP32, AMD Instinct MI350X or NVIDIA B300?
NVIDIA B300 (75 TFLOPS vs 72 TFLOPS).
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AMD Instinct MI350X
288GB HBM3e · CDNA 4
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NVIDIA B300
288GB HBM3e · Blackwell Ultra
|
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|---|---|---|---|
| Specifications | |||
| Manufacturer | AMD | NVIDIA | |
| Architecture | CDNA 4 | Blackwell Ultra | |
| VRAM | 288 GB HBM3e | 288 GB HBM3e | |
| Memory Bandwidth | 8,000 GB/s | 8,000 GB/s | |
| FP16 (Tensor) | 1800.0 TFLOPS | 2250.0 TFLOPS | |
| FP32 | 72.0 TFLOPS | 75.0 TFLOPS | |
| TDP | 1000W | 1400W | |
| Release Year | 2025 | 2025 | |
| Segment | Data center | Data center | |
| Best For | Next-gen AI training inference at scale | Frontier AI training largest model workloads | |
| Cloud Pricing | |||
| Cheapest On-Demand | — | — | |
| Cheapest Spot | — | — | |
| Providers | 1 | 1 | |
AMD Instinct MI350X
NVIDIA B300