AMD Instinct MI355X vs NVIDIA GeForce RTX 4080 — GPU Comparison (Jul 2026)
AMD Instinct MI355X (288GB HBM3e, 1,800 TFLOPS FP16, CDNA 4) vs NVIDIA GeForce RTX 4080 (16GB GDDR6X, 48.7 TFLOPS FP16, Ada Lovelace). Cloud pricing: AMD Instinct MI355X from $2.59/hr. Compare specs, VRAM, performance, and pricing across 1 cloud providers to find the best GPU for your AI workload.
Bottom Line: AMD Instinct MI355X vs NVIDIA GeForce RTX 4080
AMD Instinct MI355X comes out ahead overall, leading in 5 of 6 compared categories.
Where AMD Instinct MI355X leads
- FP16 (1,800 TFLOPS vs 48.7 TFLOPS)
- VRAM (288 GB vs 16 GB)
- Memory Bandwidth (8,000 GB/s vs 717 GB/s)
- FP32 (72 TFLOPS vs 24.4 TFLOPS)
- Release Year (2025 vs 2022)
Where NVIDIA GeForce RTX 4080 leads
- TDP (320W vs 1400W)
Choose AMD Instinct MI355X for Frontier AI training, highest-end AMD workloads. Choose NVIDIA GeForce RTX 4080 for Gaming, inference, fine-tuning.
Frequently Asked Questions
Is AMD Instinct MI355X or NVIDIA GeForce RTX 4080 better?
AMD Instinct MI355X leads in 5 of 6 compared categories. The right choice still depends on the factors that matter most to you.
Which has a better FP16, AMD Instinct MI355X or NVIDIA GeForce RTX 4080?
AMD Instinct MI355X (1,800 TFLOPS vs 48.7 TFLOPS).
Which has a better VRAM, AMD Instinct MI355X or NVIDIA GeForce RTX 4080?
AMD Instinct MI355X (288 GB vs 16 GB).
|
AMD Instinct MI355X
288GB HBM3e · CDNA 4
|
NVIDIA GeForce RTX 4080
16GB GDDR6X · Ada Lovelace
|
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|---|---|---|---|
| Specifications | |||
| Manufacturer | AMD | NVIDIA | |
| Architecture | CDNA 4 | Ada Lovelace | |
| VRAM | 288 GB HBM3e | 16 GB GDDR6X | |
| Memory Bandwidth | 8,000 GB/s | 717 GB/s | |
| FP16 (Tensor) | 1800.0 TFLOPS | 48.7 TFLOPS | |
| FP32 | 72.0 TFLOPS | 24.4 TFLOPS | |
| TDP | 1400W | 320W | |
| Release Year | 2025 | 2022 | |
| Segment | Data center | Consumer | |
| Best For | Frontier AI training highest-end AMD workloads | Gaming inference fine-tuning | |
| Cloud Pricing | |||
| Cheapest On-Demand | $2.59/hr | — | |
| Cheapest Spot | — | — | |
| Providers | 1 | 0 | |
| Provider Pricing (On-Demand) | |||
|
$2.59/hr | N/A | |
AMD Instinct MI355X
NVIDIA GeForce RTX 4080