AMD Instinct MI350X vs NVIDIA L4 — GPU Comparison (Jul 2026)
AMD Instinct MI350X (288GB HBM3e, 1,800 TFLOPS FP16, CDNA 4) vs NVIDIA L4 (24GB GDDR6, 121 TFLOPS FP16, Ada Lovelace). Cloud pricing: NVIDIA L4 from $0.39/hr. Compare specs, VRAM, performance, and pricing across 1 cloud providers to find the best GPU for your AI workload.
Bottom Line: AMD Instinct MI350X vs NVIDIA L4
AMD Instinct MI350X comes out ahead overall, leading in 5 of 6 compared categories.
Where AMD Instinct MI350X leads
- FP16 (1,800 TFLOPS vs 121 TFLOPS)
- VRAM (288 GB vs 24 GB)
- Memory Bandwidth (8,000 GB/s vs 300 GB/s)
- FP32 (72 TFLOPS vs 30.3 TFLOPS)
- Release Year (2025 vs 2023)
Where NVIDIA L4 leads
- TDP (72W vs 1000W)
Choose AMD Instinct MI350X for Next-gen AI training, inference at scale. Choose NVIDIA L4 for Inference, video transcoding, lightweight AI workloads.
Frequently Asked Questions
Is AMD Instinct MI350X or NVIDIA L4 better?
AMD Instinct MI350X leads in 5 of 6 compared categories. The right choice still depends on the factors that matter most to you.
Which has a better FP16, AMD Instinct MI350X or NVIDIA L4?
AMD Instinct MI350X (1,800 TFLOPS vs 121 TFLOPS).
Which has a better VRAM, AMD Instinct MI350X or NVIDIA L4?
AMD Instinct MI350X (288 GB vs 24 GB).
|
AMD Instinct MI350X
288GB HBM3e · CDNA 4
|
NVIDIA L4
24GB GDDR6 · Ada Lovelace
|
||
|---|---|---|---|
| Specifications | |||
| Manufacturer | AMD | NVIDIA | |
| Architecture | CDNA 4 | Ada Lovelace | |
| VRAM | 288 GB HBM3e | 24 GB GDDR6 | |
| Memory Bandwidth | 8,000 GB/s | 300 GB/s | |
| FP16 (Tensor) | 1800.0 TFLOPS | 121.0 TFLOPS | |
| FP32 | 72.0 TFLOPS | 30.3 TFLOPS | |
| TDP | 1000W | 72W | |
| Release Year | 2025 | 2023 | |
| Segment | Data center | Data center | |
| Best For | Next-gen AI training inference at scale | Inference video transcoding lightweight AI workloads | |
| Cloud Pricing | |||
| Cheapest On-Demand | — | $0.39/hr | |
| Cheapest Spot | — | — | |
| Providers | 1 | 1 | |
| Provider Pricing (On-Demand) | |||
|
N/A | $0.39/hr | |
AMD Instinct MI350X
NVIDIA L4