AMD Instinct MI325X vs NVIDIA B300 — GPU Comparison (Jul 2026)
AMD Instinct MI325X (256GB HBM3e, 1,307 TFLOPS FP16, CDNA 3) vs NVIDIA B300 (288GB HBM3e, 2,250 TFLOPS FP16, Blackwell Ultra). Cloud pricing: AMD Instinct MI325X from $2.00/hr. Compare specs, VRAM, performance, and pricing across 1 cloud providers to find the best GPU for your AI workload.
Bottom Line: AMD Instinct MI325X vs NVIDIA B300
NVIDIA B300 comes out ahead overall, leading in 4 of 6 compared categories.
Where AMD Instinct MI325X leads
- FP32 (163.4 TFLOPS vs 75 TFLOPS)
- TDP (1000W vs 1400W)
Where NVIDIA B300 leads
- FP16 (2,250 TFLOPS vs 1,307 TFLOPS)
- VRAM (288 GB vs 256 GB)
- Memory Bandwidth (8,000 GB/s vs 6,000 GB/s)
- Release Year (2025 vs 2024)
Choose AMD Instinct MI325X for AI training, large model inference. Choose NVIDIA B300 for Frontier AI training, largest model workloads.
Frequently Asked Questions
Is AMD Instinct MI325X or NVIDIA B300 better?
NVIDIA B300 leads in 4 of 6 compared categories. The right choice still depends on the factors that matter most to you.
Which has a better FP16, AMD Instinct MI325X or NVIDIA B300?
NVIDIA B300 (2,250 TFLOPS vs 1,307 TFLOPS).
Which has a better VRAM, AMD Instinct MI325X or NVIDIA B300?
NVIDIA B300 (288 GB vs 256 GB).
|
AMD Instinct MI325X
256GB HBM3e · CDNA 3
|
NVIDIA B300
288GB HBM3e · Blackwell Ultra
|
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|---|---|---|---|
| Specifications | |||
| Manufacturer | AMD | NVIDIA | |
| Architecture | CDNA 3 | Blackwell Ultra | |
| VRAM | 256 GB HBM3e | 288 GB HBM3e | |
| Memory Bandwidth | 6,000 GB/s | 8,000 GB/s | |
| FP16 (Tensor) | 1307.0 TFLOPS | 2250.0 TFLOPS | |
| FP32 | 163.4 TFLOPS | 75.0 TFLOPS | |
| TDP | 1000W | 1400W | |
| Release Year | 2024 | 2025 | |
| Segment | Data center | Data center | |
| Best For | AI training large model inference | Frontier AI training largest model workloads | |
| Cloud Pricing | |||
| Cheapest On-Demand | $2.00/hr | — | |
| Cheapest Spot | — | — | |
| Providers | 2 | 1 | |
| Provider Pricing (On-Demand) | |||
|
$2.00/hr | N/A | |
AMD Instinct MI325X
NVIDIA B300