AMD Instinct MI355X vs NVIDIA B300 — GPU Comparison (Jul 2026)
AMD Instinct MI355X (288GB HBM3e, 1,800 TFLOPS FP16, CDNA 4) vs NVIDIA B300 (288GB HBM3e, 2,250 TFLOPS FP16, Blackwell Ultra). Cloud pricing: AMD Instinct MI355X from $2.59/hr. Compare specs, VRAM, performance, and pricing across 1 cloud providers to find the best GPU for your AI workload.
Bottom Line: AMD Instinct MI355X vs NVIDIA B300
NVIDIA B300 comes out ahead overall, leading in 2 of 2 compared categories.
Where AMD Instinct MI355X leads
No clear advantages in the compared data.
Where NVIDIA B300 leads
- FP16 (2,250 TFLOPS vs 1,800 TFLOPS)
- FP32 (75 TFLOPS vs 72 TFLOPS)
Choose AMD Instinct MI355X for Frontier AI training, highest-end AMD workloads. Choose NVIDIA B300 for Frontier AI training, largest model workloads.
Frequently Asked Questions
Is AMD Instinct MI355X or NVIDIA B300 better?
NVIDIA B300 leads in 2 of 2 compared categories. The right choice still depends on the factors that matter most to you.
Which has a better FP16, AMD Instinct MI355X or NVIDIA B300?
NVIDIA B300 (2,250 TFLOPS vs 1,800 TFLOPS).
Which has a better FP32, AMD Instinct MI355X or NVIDIA B300?
NVIDIA B300 (75 TFLOPS vs 72 TFLOPS).
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AMD Instinct MI355X
288GB HBM3e · CDNA 4
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NVIDIA B300
288GB HBM3e · Blackwell Ultra
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|---|---|---|---|
| Specifications | |||
| Manufacturer | AMD | NVIDIA | |
| Architecture | CDNA 4 | Blackwell Ultra | |
| VRAM | 288 GB HBM3e | 288 GB HBM3e | |
| Memory Bandwidth | 8,000 GB/s | 8,000 GB/s | |
| FP16 (Tensor) | 1800.0 TFLOPS | 2250.0 TFLOPS | |
| FP32 | 72.0 TFLOPS | 75.0 TFLOPS | |
| TDP | 1400W | 1400W | |
| Release Year | 2025 | 2025 | |
| Segment | Data center | Data center | |
| Best For | Frontier AI training highest-end AMD workloads | Frontier AI training largest model workloads | |
| Cloud Pricing | |||
| Cheapest On-Demand | $2.59/hr | — | |
| Cheapest Spot | — | — | |
| Providers | 1 | 1 | |
| Provider Pricing (On-Demand) | |||
|
$2.59/hr | N/A | |
AMD Instinct MI355X
NVIDIA B300