AMD Instinct MI350X vs NVIDIA RTX A4000 — GPU Comparison (Jul 2026)
AMD Instinct MI350X (288GB HBM3e, 1,800 TFLOPS FP16, CDNA 4) vs NVIDIA RTX A4000 (16GB GDDR6, 19.2 TFLOPS FP16, Ampere)
Bottom Line: AMD Instinct MI350X vs NVIDIA RTX A4000
AMD Instinct MI350X comes out ahead overall, leading in 5 of 6 compared categories.
Where AMD Instinct MI350X leads
- FP16 (1,800 TFLOPS vs 19.2 TFLOPS)
- VRAM (288 GB vs 16 GB)
- Memory Bandwidth (8,000 GB/s vs 448 GB/s)
- FP32 (72 TFLOPS vs 16 TFLOPS)
- Release Year (2025 vs 2021)
Where NVIDIA RTX A4000 leads
- TDP (140W vs 1000W)
Choose AMD Instinct MI350X for Next-gen AI training, inference at scale. Choose NVIDIA RTX A4000 for Entry workstation, rendering.
Frequently Asked Questions
Is AMD Instinct MI350X or NVIDIA RTX A4000 better?
AMD Instinct MI350X leads in 5 of 6 compared categories. The right choice still depends on the factors that matter most to you.
Which has a better FP16, AMD Instinct MI350X or NVIDIA RTX A4000?
AMD Instinct MI350X (1,800 TFLOPS vs 19.2 TFLOPS).
Which has a better VRAM, AMD Instinct MI350X or NVIDIA RTX A4000?
AMD Instinct MI350X (288 GB vs 16 GB).
|
AMD Instinct MI350X
288GB HBM3e · CDNA 4
|
NVIDIA RTX A4000
16GB GDDR6 · Ampere
|
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|---|---|---|---|
| Specifications | |||
| Manufacturer | AMD | NVIDIA | |
| Architecture | CDNA 4 | Ampere | |
| VRAM | 288 GB HBM3e | 16 GB GDDR6 | |
| Memory Bandwidth | 8,000 GB/s | 448 GB/s | |
| FP16 (Tensor) | 1800.0 TFLOPS | 19.2 TFLOPS | |
| FP32 | 72.0 TFLOPS | 16.0 TFLOPS | |
| TDP | 1000W | 140W | |
| Release Year | 2025 | 2021 | |
| Segment | Data center | Professional | |
| Best For | Next-gen AI training inference at scale | Entry workstation rendering | |
| Cloud Pricing | |||
| Cheapest On-Demand | — | — | |
| Cheapest Spot | — | — | |
| Providers | 1 | 0 | |
AMD Instinct MI350X
NVIDIA RTX A4000