AMD Instinct MI350X vs NVIDIA RTX 4500 Ada — GPU Comparison (Jul 2026)
AMD Instinct MI350X (288GB HBM3e, 1,800 TFLOPS FP16, CDNA 4) vs NVIDIA RTX 4500 Ada (24GB GDDR6, 31.7 TFLOPS FP16, Ada Lovelace)
Bottom Line: AMD Instinct MI350X vs NVIDIA RTX 4500 Ada
AMD Instinct MI350X comes out ahead overall, leading in 5 of 6 compared categories.
Where AMD Instinct MI350X leads
- FP16 (1,800 TFLOPS vs 31.7 TFLOPS)
- VRAM (288 GB vs 24 GB)
- Memory Bandwidth (8,000 GB/s vs 432 GB/s)
- FP32 (72 TFLOPS vs 23.8 TFLOPS)
- Release Year (2025 vs 2024)
Where NVIDIA RTX 4500 Ada leads
- TDP (210W vs 1000W)
Choose AMD Instinct MI350X for Next-gen AI training, inference at scale. Choose NVIDIA RTX 4500 Ada for CAD, visualization, light AI.
Frequently Asked Questions
Is AMD Instinct MI350X or NVIDIA RTX 4500 Ada better?
AMD Instinct MI350X leads in 5 of 6 compared categories. The right choice still depends on the factors that matter most to you.
Which has a better FP16, AMD Instinct MI350X or NVIDIA RTX 4500 Ada?
AMD Instinct MI350X (1,800 TFLOPS vs 31.7 TFLOPS).
Which has a better VRAM, AMD Instinct MI350X or NVIDIA RTX 4500 Ada?
AMD Instinct MI350X (288 GB vs 24 GB).
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AMD Instinct MI350X
288GB HBM3e · CDNA 4
|
NVIDIA RTX 4500 Ada
24GB GDDR6 · Ada Lovelace
|
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|---|---|---|---|
| Specifications | |||
| Manufacturer | AMD | NVIDIA | |
| Architecture | CDNA 4 | Ada Lovelace | |
| VRAM | 288 GB HBM3e | 24 GB GDDR6 | |
| Memory Bandwidth | 8,000 GB/s | 432 GB/s | |
| FP16 (Tensor) | 1800.0 TFLOPS | 31.7 TFLOPS | |
| FP32 | 72.0 TFLOPS | 23.8 TFLOPS | |
| TDP | 1000W | 210W | |
| Release Year | 2025 | 2024 | |
| Segment | Data center | Professional | |
| Best For | Next-gen AI training inference at scale | CAD visualization light AI | |
| Cloud Pricing | |||
| Cheapest On-Demand | — | — | |
| Cheapest Spot | — | — | |
| Providers | 1 | 0 | |
AMD Instinct MI350X
NVIDIA RTX 4500 Ada