AMD Instinct MI350X vs NVIDIA RTX 4000 Ada — GPU Comparison (Apr 2026)
AMD Instinct MI350X (288GB HBM3e, 1,800 TFLOPS FP16, CDNA 4) vs NVIDIA RTX 4000 Ada (20GB GDDR6, 107 TFLOPS FP16, Ada Lovelace). Cloud pricing: NVIDIA RTX 4000 Ada from $0.76/hr. Compare specs, VRAM, performance, and pricing across 1 cloud providers to find the best GPU for your AI workload.
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AMD Instinct MI350X
288GB HBM3e · CDNA 4
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NVIDIA RTX 4000 Ada
20GB GDDR6 · Ada Lovelace
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| Specifications | |||
| Manufacturer | AMD | NVIDIA | |
| Architecture | CDNA 4 | Ada Lovelace | |
| VRAM | 288 GB HBM3e | 20 GB GDDR6 | |
| Memory Bandwidth | 8,000 GB/s | 360 GB/s | |
| FP16 (Tensor) | 1800.0 TFLOPS | 107.0 TFLOPS | |
| FP32 | 72.0 TFLOPS | 26.7 TFLOPS | |
| TDP | 1000W | 130W | |
| Release Year | 2025 | 2023 | |
| Segment | Data center | Professional | |
| Best For | Next-gen AI training inference at scale | Entry professional AI CAD visualization | |
| Cloud Pricing | |||
| Cheapest On-Demand | — | $0.76/hr | |
| Cheapest Spot | — | — | |
| Providers | 1 | 1 | |
| Provider Pricing (On-Demand) | |||
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N/A | $0.76/hr | |
AMD Instinct MI350X
NVIDIA RTX 4000 Ada