AMD Instinct MI350X vs NVIDIA RTX 4000 Ada — GPU Comparison (Jul 2026)
AMD Instinct MI350X (288GB HBM3e, 1,800 TFLOPS FP16, CDNA 4) vs NVIDIA RTX 4000 Ada (20GB GDDR6, 107 TFLOPS FP16, Ada Lovelace). Cloud pricing: NVIDIA RTX 4000 Ada from $0.76/hr. Compare specs, VRAM, performance, and pricing across 1 cloud providers to find the best GPU for your AI workload.
Bottom Line: AMD Instinct MI350X vs NVIDIA RTX 4000 Ada
AMD Instinct MI350X comes out ahead overall, leading in 5 of 6 compared categories.
Where AMD Instinct MI350X leads
- FP16 (1,800 TFLOPS vs 107 TFLOPS)
- VRAM (288 GB vs 20 GB)
- Memory Bandwidth (8,000 GB/s vs 360 GB/s)
- FP32 (72 TFLOPS vs 26.7 TFLOPS)
- Release Year (2025 vs 2023)
Where NVIDIA RTX 4000 Ada leads
- TDP (130W vs 1000W)
Choose AMD Instinct MI350X for Next-gen AI training, inference at scale. Choose NVIDIA RTX 4000 Ada for Entry professional AI, CAD, visualization.
Frequently Asked Questions
Is AMD Instinct MI350X or NVIDIA RTX 4000 Ada better?
AMD Instinct MI350X leads in 5 of 6 compared categories. The right choice still depends on the factors that matter most to you.
Which has a better FP16, AMD Instinct MI350X or NVIDIA RTX 4000 Ada?
AMD Instinct MI350X (1,800 TFLOPS vs 107 TFLOPS).
Which has a better VRAM, AMD Instinct MI350X or NVIDIA RTX 4000 Ada?
AMD Instinct MI350X (288 GB vs 20 GB).
|
AMD Instinct MI350X
288GB HBM3e · CDNA 4
|
NVIDIA RTX 4000 Ada
20GB GDDR6 · Ada Lovelace
|
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|---|---|---|---|
| Specifications | |||
| Manufacturer | AMD | NVIDIA | |
| Architecture | CDNA 4 | Ada Lovelace | |
| VRAM | 288 GB HBM3e | 20 GB GDDR6 | |
| Memory Bandwidth | 8,000 GB/s | 360 GB/s | |
| FP16 (Tensor) | 1800.0 TFLOPS | 107.0 TFLOPS | |
| FP32 | 72.0 TFLOPS | 26.7 TFLOPS | |
| TDP | 1000W | 130W | |
| Release Year | 2025 | 2023 | |
| Segment | Data center | Professional | |
| Best For | Next-gen AI training inference at scale | Entry professional AI CAD visualization | |
| Cloud Pricing | |||
| Cheapest On-Demand | — | $0.76/hr | |
| Cheapest Spot | — | — | |
| Providers | 1 | 1 | |
| Provider Pricing (On-Demand) | |||
|
N/A | $0.76/hr | |
AMD Instinct MI350X
NVIDIA RTX 4000 Ada